Endocrine Abstracts

Background: Multiple endocrine neoplasia type 1 (MEN1) (OMIM 131100) is an autosomal dominant disorder associated with a high risk of developing parathyroid hyperplasia (90%), digestive neuroendocrine tumors (30–70%) and pituitary adenomas (30-40%). Prevalence of MEN1 is 2-10/100.000, there are no differences between men and women and usually, it is diagnosed before 40 years old. It is related to different mutations of the MEN1 tumour-suppressor gene (OMIM: 613733) which ...

Introduction: Biotin is a water-soluble vitamin involved in several and important metabolic processes, recommended daily intake for adults is 30–100 μg/day and normal plasma concentrations are 0.4–1.2 ng/day. Nowadays biotin is being used in inherited metabolic diseases, multiple sclerosis and as a supplement in, over the counter multivitamins widely used for common hair and skin problems. The supraphysiologic biotin intake has produced emerging problems with bi...